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Football will be back before you know it.
The 2026 NFL season officially kicks off on Wednesday, September 9, with the defending champion Seattle Seahawks opening the year at home against an opponent that will be revealed during the league’s official schedule release.
Australia will dip its toe into the pigskin as an NFC West battle between the San Francisco 49ers and Los Angeles Rams takes place at the Melbourne Cricket Ground on Friday, September 11.
Once the full schedule is announced on Thursday, we’ll provide complete coverage of the latest NFL Week 1 odds, betting lines, spreads, and matchup analysis for every game of the opening weekend.
NFL Week 1 Odds
Matchup
Spread
Moneyline
Over/Under
TBD
vs
Seahawks
—
—
—
49ers
vs
Rams
+2.5 -102
-2.5 -118
+124
-148
o48.5 -110
u48.5 -110
Cowboys
vs
Giants
-1.5 -115
+1.5 -105
-130
+110
o47.5 -110
u47.5 -110
Broncos
vs
Chiefs
OTB
OTB
OTB
Odds as of 5-12-2026. Odds from DraftKings, one of our best betting apps. Sign up with our DraftKings promo code, or get one of our other sportsbook promos.
Rumored Seattle Opponents
Per Mike Garafolo, the four potential teams to open the season in the Emerald City against the Seattle Seahawks have been narrowed down to the Chicago Bears, New England Patriots, Los Angeles Chargers, and Arizona Cardinals.
A potential matchup between New England and Seattle would mark the first season opener to feature a Super Bowl rematch.
Primetime Prowess
The John Harbaugh era in Gotham begins on Sunday Night Football when the New York Giants host the Dallas Cowboys.
Meanwhile, the Kansas City Chiefs are set to play host to the Denver Broncos on Monday, September 14, potentially marking the return of Patrick Mahomes.
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